Skilin 5% Cream 30gm Tube

Pharmacology of Skilin 5% Cream

Permethrin cream contains permethrin, a synthetic pyrethroid, which is effective as a topical scabicidal agent. It treats infestations caused by Sarcoptes scabiei (scabies) by disrupting the normal function of the mites' nerve cell membranes. Specifically, it interferes with sodium channels that regulate nerve membrane polarization. This disruption results in delayed repolarization and paralysis of the mites, ultimately leading to their death.

Pharmacokinetics:

Permethrin is approved for topical application only. Human data on systemic absorption or pharmacokinetics after skin application is limited. Some presystemic metabolism occurs within the skin, but less than 0.5% of the applied dose is absorbed over the first 48 hours. Any absorbed permethrin is rapidly metabolized via ester hydrolysis, likely in the liver, and its breakdown products are primarily excreted in the urine.

Dosage of Skilin 5% Cream

• Adults and children over 12 years: Apply a full tube.
• Children aged 6-12 years: Use up to half a tube.
• Children aged 1-5 years: Apply up to one-quarter of a tube.
• Children aged 2 months to 1 year: Use up to one-eighth of a tube.
• For children under 2 months, the appropriate dose is not established.

It is important to follow a doctor’s prescription when using the cream.

Administration of Skilin 5% Cream

Before applying permethrin cream, ensure the skin is clean, cool, and dry. Avoid hot showers or baths just before use.

For adults and children over 2 years: The cream should be applied to the entire body from the neck down. It should be gently rubbed into the skin until fully absorbed, covering all areas, including between fingers and toes, under the nails, and on the soles of the feet.

For babies under 2 years: Apply to the face, neck, ears, and scalp, avoiding the areas around the eyes and mouth.

Leave the cream on for at least 8 hours before washing it off. If any area of the skin is washed during this time (e.g., after handwashing), reapply the cream to that area. The treatment can be repeated after 7 days if required based on a doctor’s advice.

Interactions:

Treatment of eczema-like reactions with corticosteroids should be discontinued before using permethrin, as corticosteroids may suppress the immune response to the scabies mites, potentially worsening the infestation.

Contraindications:

Permethrin should not be used by individuals with known hypersensitivity to any components of pyrethroids or permethrin. Healthcare personnel who regularly apply permethrin may wear gloves to prevent hand irritation.

Side Effects of Skilin 5% Cream

• Skin irritation
• Redness
• Rash
• Burning or tingling sensation
• numbness

Pregnancy & Lactation

Due to the lack of specific studies in pregnant women, permethrin should only be used during pregnancy under medical supervision. It is not confirmed whether permethrin is excreted in breast milk, so nursing mothers are advised not to use the cream unless recommended by a doctor.

Precautions and Warnings:

Scabies infestations are often accompanied by itching, swelling, and redness. These symptoms may temporarily worsen following treatment with permethrin. Patients should take care to avoid contact with their eyes during application, and if the cream does get into the eyes, they should immediately rinse with water.

Storage:

Store the cream in a cool, dry place, away from light. Ensure it is kept out of the reach of children.